![]() Described are the various clinical applications of deadspace measurements in the critically unwell. This review revisits the physiological concepts and methods of measuring deadspace. Thus making it more accessible and easy to monitor and study in large groups of patients, factors which have perhaps resulted in its under-utilisation in critical care. Several indices have been described that either predict deadspace or track ventilatory efficiency at the bedside. ![]() Recently though there has been a resurgence of interest in ventilatory efficiency. Deadspace and with it ventilatory efficiency has been largely forgotten. Yet indices of oxygenation seem to be the mainstay when instigating or fine-tuning ventilatory strategies. Since its first description by Bohr in the late 19th century to the current use of single-breath test for volumetric CO 2, our understanding of the physiological deadspace has vastly improved. Measuring deadspace ventilation should be the most reliable method of monitoring ventilatory efficiency in mechanically ventilated patients. Problems with ventilatory efficiency results in abnormal CO 2 clearance.
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